Journal: Frontiers in Aging Neuroscience

Article Title: Early detection of cognitive decline in Alzheimer’s disease using eye tracking

doi: 10.3389/fnagi.2023.1123456

Figure Lengend Snippet: (A) The four images presented in the visual memory task. Blue circles, which are not visible to the subjects, indicate the informative regions of interest (ROIs) that characterize the image. We determined the locations of these informative regions based on previous studies ( ; ). The radius of these ROIs was 1.9 deg in visual angle. (B) The eye-tracking system. A 17-inch computer display is placed 50 cm in front of the subject’s eyes. The images are presented on the display, and the subject’s eye movements (fixations and saccades) while looking at the image are recorded by the video-oculography camera (Eyelink 1000 ® ). The scanned area is defined by the convex envelope of all fixation points. (C) The images used in the visual search tasks. In the serial search task, the target Landolt ring is placed upwards and others are placed downwards. In the pop-out task, the target ring is red and the others are black. In both tasks, the number of rings was 4 or 48. (D) An example of time distribution in 10 s while a subject is looking at an image. The gray bars indicate the fixation periods, and the white bars indicate other times (saccades, blinks, face displacements, and so on) that indicate failure of fixation. The red rectangle indicates the 5 s that include the longest total time duration of fixations. (E) An example of a pupil size plot during the visual search task. Pupil size data (blue line) cannot be recorded during blinks (arrow). The red line is the upper envelope of pupil size data, which is not influenced by saccades.

Article Snippet: We used the Eyelink Data viewer software (ver1.3.37, SR Research, Mississauga, Ontario, Canada) for data processing.

Techniques: